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首页> 外文OA文献 >Investigation of the in vitro photocatalytic antibacterial activity of nanocrystalline TiO2 and coupled TiO2/Ag containing copolymer on the surface of medical grade titanium
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Investigation of the in vitro photocatalytic antibacterial activity of nanocrystalline TiO2 and coupled TiO2/Ag containing copolymer on the surface of medical grade titanium

机译：医用钛表面纳米晶TiO2和含TiO2 / Ag的共聚物的体外光催化抗菌性能研究。

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Antibacterial surfaces have been in the focus of research for years, driven by an unmet clinical need to manage an increasing incidence of implant-associated infections. The use of silver has become a topic of interest because of its proven broad-spectrum antibacterial activity and track record as a coating agent of soft tissue implants and catheters. However, for the time being, the translation of these technological achievements for the improvement of the antibacterial property of hard tissue titanium (Ti) implants remains unsolved. In our study, we focused on the investigation of the photocatalysis mediated antibacterial activity of silver (Ag), and Ti nanoparticles instead of their pharmacological effects. We found that the photosensitisation of commercially pure titanium discs by coating them with an acrylate-based copolymer that embeds coupled Ag/Ti nanoparticles can initiate the photocatalytic decomposition of adsorbed S. salivarius after the irradiation with an ordinary visible light source. The clinical isolate of S. salivarius was characterised with MALDI-TOF mass spectrometer, while the multiplication of the bacteria on the surface of the discs was followed-up by MTT assay. Concerning practical relevance, the infected implant surfaces can be made accessible and irradiated by dental curing units with LED and plasma arc light sources, our research suggests that photocatalytic copolymer coating films may offer a promising solution for the improvement of the antibacterial properties of dental implants.
机译：由于未满足的临床需要来管理与植入物相关的感染的增加，因此抗菌表面一直是研究的重点。由于银已被证明具有广谱抗菌活性，并且作为软组织植入物和导管的涂层剂具有良好的记录，因此银的使用已成为人们关注的话题。然而，暂时而言，这些技术成果对改善硬组织钛（Ti）植入物的抗菌性能的翻译仍未解决。在我们的研究中，我们专注于研究光催化介导的银（Ag）和Ti纳米颗粒的抗菌活性，而不是其药理作用。我们发现，通过用嵌入偶联的Ag / Ti纳米粒子的丙烯酸酯基共聚物涂覆商业纯钛圆片，可以对它们进行光敏化，从而可以在用普通可见光源照射后引发唾液沙门氏菌的光催化分解。唾液链球菌的临床分离株用MALDI-TOF质谱仪进行了表征，而圆盘表面细菌的繁殖则通过MTT法进行了跟踪。关于实用性，可以通过牙科固化装置使用LED和等离子弧光源使被感染的植入物表面接近并照射，我们的研究表明，光催化共聚物涂膜可能为改善牙科植入物的抗菌性能提供有希望的解决方案。

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